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Although radiotherapy-induced ICD is restricted by the immunosuppressive tumor microenvironment, its combination with immunotherapy effectively diminishes Treg infiltration, facilitates DC maturation, and substantially enhances the abscopal effects of radiotherapy [463, 464]

LA exhibits various anti-inflammatory effects and offers protection to mitochondria

Widely used in animal husbandry, the synthetic compound known as menadione (vitamin K 3 ) is a provitamin that needs to be converted to menaquinone-4 to be active (Table 6) (Rishavy et al

This is one of the most widespread misconceptions

Notwithstanding, some clinically relevant complex I inhibitors such as metformin, MS-L6 and IACS-010759 have shown low toxicity in vitro in mouse liver organoids, rat hepatocytes, non tumoral human cells (lymphocytes, skin fibroblast, lung fibroblast) and murine embryonic fibroblasts in comparison with rotenone (5961), and their administration inhibits tumor growth in murine xenograft models (human colon cancer, human non-Hodgkins B-cell lymphoma cancer, acute myeloid leukemia, glioblastoma and neuroblastoma) without toxicity (56, 59, 61)