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Once absorbed, heme can be transported from vesicles to the cytoplasm via heme-responsive gene 1 (HRG-1) and subsequently metabolized by heme oxygenase 1 (HO-1) in the endoplasmic reticulum, releasing ferrous ions that contribute to the cytoplasmic iron pool

Organization, The global burden of disease: 2004 update, 2008

Pediatr Diabetes 20(7):815-20 2019 PMC6786918 Tonnies T, Imperatore G, Hoyer A, Saydah SH, D'Agostino RB, Jr., Divers J, Isom S, Dabelea D, Lawrence JM, Mayer-Davis EJ, Pihoker C, Dolan L, Brinks R

Dosage and Frequency Once a week Taken on the same day each week, any time of day, with or without food

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