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Nov 16 2019;11(11)doi:10.3390/nu11112800

Several studies have pointed out that ASD subjects of all ages present nutritional abnormalities and redox imbalances caused by the dysfunctional mitochondria ( Several studies have proposed that ASD may involve different biological profiles, including alterations in redox balance, mitochondrial dysfunction and immune-inflammatory signaling

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Maruyama T, Maruyama N, Higuchi T, et al

Recent studies have pointed out the changing natural history of DN with the advent of therapeutic lifestyle change and the use of statins and ACE inhibitors, which have slowed the progression of DN and drastically changed the requirements for placebo-controlled studies 35