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Although randomized studies have not shown an overall effect on the frequency of exacerbations, a post-hoc analysis of a clinical trial reported a decrease in their severity (87) Overall, these results demonstrate that A1PI augmentation therapy offers significant benefits in slowing the progression of emphysema and improving clinical outcomes for patients with AATD, underscoring the importance of timely and continuous treatment

For ipamorelin , several clinical studies and trials looked at its safety and targeted uses (e.g., gastrointestinal prokinetic effects, postoperative ileus)

Further, African green monkeys with pre-existing antibody and/or T cells after primary SARS-CoV infection were protected from homologous re-challenge as assessed by lung virus titres, although the pulmonary inflammatory response was not different from that of primary infection 128

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10.1016/j.jneuroim.2015.10.001 95