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Some clients may experience injection site irritation, mild headache or fatigue, transient changes in dream vividness, or occasional mood shifts

In animals, sleep deprivation also leads to upregulation of -secretase 1 (BACE-1), the most important enzyme regulating A generation in the brain 142,143,149 , thus opening the hypothesis of increased A production by sleep deprivation

[DOI] [PMC free article] [PubMed] [Google Scholar] 51.Frampton G.M., Ali S.M., Rosenzweig M., Chmielecki J., Lu X., Bauer T.M., Akimov M., Bufill J.A., Lee C., Jentz D., et al

[DOI] [PubMed] [Google Scholar] 168.Sorg O., Horn T.F., Yu N., Gruol D.L., Bloom F.E