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Description
Nobiletin, a citrus polymethoxy flavone, phosphorylated Ser 19 and Ser 40 of TH and increased TH activity in cultured bovine adrenal medullary cells by PKA [153]
Ursini et al., 2016
Both observed behaviors originated from central nervous alterations such as cholinergic signaling
The concern with long-term administration is not receptor fatigue it is copper accumulation
The baffling aspect of this disease is the great heterogeneity of response among patients, ranging from severe symptoms to asymptomatic progression
