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However, the findings have been inconsistent with partly modest sample sizes (16)
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However, the expression trends of cdk4 , cdk6 , e2f1 , and rb1 in many other cancers were inconsistent, indicating that this signaling pathway may regulate the cell cycle by crossing with other signaling pathways, and CDK4/6 inhibitor combination therapies may lead to considerable antitumor effects in these cancers (Fig

doi: 10.1016/0002-9343(91)90469-E
