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This favorable preclinical safety profile has led investigators to advocate for the initiation of formal human trials [52, 83]

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Graf and Kastin documented that DSIP affects not just sleep itself but the neuroendocrine systems that govern sleep including ACTH, growth hormone release patterns, and circadian oscillators (Graf & Kastin, 1984)

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In several studies, levels of DSIP in the plasma and cerebrospinal fluid are significantly deviated from the norm in patients with MDD, though there are contradictions as to whether levels are higher or lower than healthy control patients

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