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9,19 There are no prospective randomized studies on the safety of cimetidine and other H 2 RAs during pregnancy, but the general consensus is that cimetidine and possibly famotidine are safe
doi: 10.1016/0306-4530(85)90052-6
Hudgens JL, Sugg KB, Grekin JA, Gumucio JP, Bedi A, Mendias CL

Indeed, preclinical studies conducted in renal carcinoma model reported that the VEGFR2 inhibitor sunitinib increases vascular mimicry under hypoxia by transforming tumor cells into endothelial-like cells resulting in tumor resistance [301]
