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During PDT, oxygen consumption increases local hypoxia, thereby activating TPZ and achieving synergistic photodynamic and chemotherapeutic effects [291]

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To assess this issue, we crossed Stard7 Lox/lox or Stard7 IEC mice with the Apc +/Min strain which spontaneously develops intestinal adenomas due to constitutive Wnt signaling (Su et al, 1992)

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