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Vasquez-Dunddel D, Pan F, Zeng Q, Gorbounov M, Albesiano E, Fu J, Blosser RL, Tam AJ, Bruno T, Zhang H, Pardoll D, Kim Y
Indeed, when 2-DG and metformin simultaneously target glycolysis and mitochondrial complex I, T cell metabolism is normalized and lupus disease is reduced in mice, thus highlighting the importance of both glycolysis and mitochondrial metabolism in T cell function and autoimmune diseases (74, 76)
Due to their instability, these compounds rapidly degrade into toxic end-products such as malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) [117, 118]
Sampson, D
