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Upon the release of zonulin into the lumen as a result of intestinal exposure to gliadin, zonulin can interact with two receptors, epidermal growth factor receptor (EGFR) and protease-activated receptor 2 (PAR2), which results in increased intestinal permeability (27, 32)

Yet even more effective is its role as an opponent of free radicals and its effect in combatting nitrosative stress an underestimated and possibly central element in the development of many diseases

88,89 A scaffold should provide architecture and support for initial load-bearing, but exhibit a degradation profile that allows infiltrated cells to respond and form neo-cartilage tissue

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