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Less common, whole-body effects

For example, we have demonstrated that CD38 is responsible for the synthesis of isoniazid derivatives of NAD + and NADP + in animals given toxic doses of this anti-tuberculosis medication (37)

Nat Rev Dis Primers 6

B12-downregulated genes in this group were related to positive regulation of transcription by RNA polymerase II, processing and transport of mRNA, mRNA splicing, cellular response to DNA damage stimulus, activation of innate immune response, positive regulation of IL-6 and IL-2 production, T-cell differentiation in thymus, histone modification, viral transcription and DNA conformational change