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Three members of the TGF family (TGF1, 2, 3) promote LOX and LOXL1-4 expression in human trabecular meshwork (sponge-like connective tissue located in the proximal side of the eye) cells via both Smad and non-Smad pathways (MAPK/JNK and AP-1) through TGFR1 and TGFR2 (Sethi et al ., 2011)

[DOI] [PubMed] [Google Scholar] 113.Tirado-Sanchez A, Santamaria-Roman A, Ponce-Olivera RM

The rising prevalence of vitamin B12 deficiency is expected to drive growth in the pernicious anemia diagnosis and treatment market going forward

To further validate cathepsin Bs specific role, we also utilized AAV-mediated overexpression of cathepsin B and its inhibitor cystatin A, which supports our findings