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Levodopa Levodopa has been shown in numerous placebo-controlled randomised trials to be effective in treating RLS (Limousin et al., 2018) levodopa was found to be useful in treating nocturnal symptoms of restless legs syndrome as well as improving both the subjective and objective quality of sleep-in patients with idiopathic and uraemic disease

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Interestingly, this interaction is usually bidirectional, whereby immune cells also influence fibroblast behaviour ( in vitro cultures, Zhou et al

Acral vitiliginous lesions, located on the wrist, hand, ankle, and foot, are often resistant to medical therapies, probably due to their lower content of melanocytes and hair follicles, which harbor melanocyte stem cells