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elegans , and aged mice with trigonelline resulted in increased NAD + levels and enhanced mitochondrial function through the PreissHandler pathway, and improved muscle aging phenotypes 124

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doi: 10.1016/S0092-8674(00)81532-9 13 LiYChenGMaLOhmsSJSunCShannonMFet al

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In its extremes, absence or excess of IGF-1 results in serious growth abnormalities, especially in children

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