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Proc Am Soc Clin Oncol:319s, 2005

To improve the selectivity, in this work, we design and synthesize a malononitrile-functionalized TPE derivative, TPE-DCV, which can undergo addition reaction with thiol group to the alkene bond, leading to the change in its fluorescence in the system (Figure 1)

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Among divalent cations, magnesium (Mg 2+ ) is thought to be the most suitable for neutralizing the intrinsic negative charge of the RNA phosphate backbone due to its abundant intracellular concentrations (174)