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10.3389/fnut.2021.627289 102 RiedelC.-U.FoataF.PhilippeD.AdolfssonO.EikmannsB.-J.BlumS

Aside from direct effects on principal neurons, a second, hypothesized mechanism for ketamines antidepressant effect is an indirect impact on principal excitatory neurons via inhibition of fast spiking PV-positive interneurons resulting in cortical disinhibition [171,172,173]

Pulmonary vascular remodeling is driven by a NF-B -dependent signaling axis, which is initiated by its nuclear translocation and subsequent pro-inflammatory gene activation

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