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Interestingly, a previous analysis of Salmonella growth curves indicated that the upregulation of SOS and oxidative stress genes due to cystine addition did not significantly impact bacterial division and growth

Environment-responsive release: pH-sensitive nanocarriers (e.g., FeO/chitosan/TiO 2 composites) trigger drug release in acidic microenvironments (e.g., inflammation sites and crystal deposits), enhancing local efficacy (Mohamadi Bian and Moghadam, 2025

Most protocols include periodic breaks or cycling strategies to maintain pituitary responsiveness