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Oligodendrocytes support axonal transport and maintenance via exosome secretion

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The accumulation of -Syn in excess is known to interact with the mitochondrial outer membrane, resulting in mitochondrial fragmentation (ODonnell et al., 2014

When a mouse carrying a xenograft produced by a mixture of HCTT16 WT and HCT116 p53 -/ p53 - is treated with an anti VEGF antibody an initial shrinkage of the tumour occurs as most of the WT-hypoxia sensitive cells undergo apoptosis