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Inability to produce NADPH due to glucose 6-phosphate dehydrogenase (G6PD) deficiency renders an individual prone to infections, presumably due to reduced activity of NOX2, and susceptible to oxidative stress due to reduced activity of glutathione peroxidases (Luzzatto et al

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Given that these species can accumulate not only through increased production but also through decreased clearance, an inadequate antioxidant response, particularly associated with a dysregulation of NRF2 transcriptional activity, could explain their gradual accumulation

Lifestyle factors, including stress and diet, significantly influence your bodys glutathione needs