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This is a naturally occurring copper complex that was first isolated from human plasma

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New possible mechanisms of tumor escape from antiangiogenic therapy include: EC heterogeneity, antiangiogenic VEGF, extracellular vesicles, lysosomal sequestration, glycosylation-dependent resistance and genetic polymorphism (reviewed in ref

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His argument is straightforward

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In experimental models, it is studied in connection with cellular regeneration, tissue protection, and stress responses

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