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A systematic review of the global economic burden of ADHD reported per person total costs ranging from $US831.38 to 20,538 and national estimates ranging from $US356 million to 20.27 billion [3]

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How oxidation and reduction are balanced within the ER lumen is not well-understood, and that understanding is confounded by the observations that neither ablation of both ERO1 isoforms (Zito, Chin, Blais, Harding, & Ron, 2010) nor apparent depletion of total ER glutathione (Tsunoda et al., 2014) appreciably impacts ER protein oxidation capacity or stress sensitivity except for specialized substrates

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