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Redox regulation of transcription ROS modulate the activity of redox-sensitive transcription factors (TFs), such as Nrf2, NF-B, HIF1, and FOXO, either through posttranslational modifications (PTMs) or by impacting upstream signaling pathways (such as Keap1 in Nrf2 signaling, IKK in NF-B signaling, and PHD2 in HIF1 signaling)