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Surface plasmon resonance (SPR) kinetic measurements confirmed the higher affinities and slower dissociation rates of AETX-R114 compared with AETX-R023, with picomolar K D values at 37 C for both soto-p 7 /A*03 (7 pM) and soto-p 7 /A*11 (160 pM)

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In particularly, ACSL4 plays a crucial role in regulating ferroptosis, and its overexpression boosts the synthesis of -pufa6 PUFA and encourages ferroptosis (51)

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