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But AOD 9604 makes those efforts more effective at actually burning fat rather than just losing weight (which often includes muscle)

BioMed research international , 2021 , 9924314

Cecal levels of Akkermansia muciniphila have been strongly correlated with physiological metrics including glycemia and insulinemia 89 , and Akkermansia has correlated negatively with obesity-related measures 90 and has been implicated in DIO prevention 91,92

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This allows researchers to isolate metabolic signaling effects without confounding endocrine responses, making AOD 9604 a useful model for studying localized metabolic regulation