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Structure-activity relationship studies have led to the discovery of non-pyridyl class NAMPT activators, which suggest a through-water interaction mechanism within the NAMPT active site 223
10.1016/j.cell.2011.08.039 198 PowersM.MinchellaD.Gonzalez-AcevedoM.Escutia-PlazaD.WuJ.HegerC.et al (2023)
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Animal reproduction studies have not been conducted with ADVATE

doi: 10.1074/jbc.M900392200