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According to the theory of retrograde menstruation, components of refluxed blood, including apoptotic endometrial tissue, desquamated menstrual cells, lysed erythrocytes, and released iron, induce inflammation in the peritoneal cavity
Subsequently, tyrosines 1349 and 1356 in the carboxy-terminal tail become phosphorylated
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76 In a cell experiment, when renal tubular cells experienced hypoxia and then reoxygenation, the levels of HIF-1 and BNIP3 were increased, mediating mitophagy, which could protect cells from cell apoptosis