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For SPCD, treatment directly addresses the biological deficit

J Expo Sci Environ Epidemiol

In all cases, single and double mutants were homozygous for each mutation except strains containing rab-7(ok511) , cup-5(zu223) , and some strains containing ccz-1(ok2182) , which were kept heterozygous due to the recessive maternal effect lethality or severe growth defect caused by these mutations [54, 57, 86]

(17(2)):e79318 doi:10.7759/cureus.79318

Neuronal subclass-selective loss of pyruvate dehydrogenase immunoreactivity following canine cardiac arrest and resuscitation
