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42 1 Integrin on tumour cells can also enhance vascular co-option by mediating adhesion to the vascular basement membrane (BM)

The PPP is also important for maintaining redox balance of cells, including the control of the antioxidant thioredoxin and glutathione systems shown to regulate HIV replication and latency in CD4 + T cells and macrophages 99,100

Additionally, mitochondrial enzymes, particularly SOD, neutralize superoxide radicals, generating oxygen and hydrogen peroxide

Biochem J 373(Pt 3):957963

however, results were insignificant, indicating that individual and combined ozone and 5-FU use had no effect on glioma cells (26)