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The gamma linkage (between glutamate's side-chain carboxyl group and cysteine's amino group) was unusual and made the molecule resistant to standard peptidases, which explained why it accumulated in cells rather than being rapidly degraded

When episodes of major depression are chronic and recurring, the condition is called persistent depressive disorder

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However, we found that using spectral libraries built from other species as the decoy might violate the underlying assumptions of target-decoy search strategy and lead to biased results

doi: 10.3892/or.2012.2034 162