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231 Mechanistically, ketones produced by liver metabolism act as both energy supply molecules and signal molecules involved in binding G protein-coupled receptors, inhibiting HDACs, regulating the abundance of intestinal microbiota, improving intestinal barrier function, and reducing the production of ROS and free radicals

[CrossRef] [PubMed] [Google Scholar] Studies on free radicals, antioxidants, and cofactors

In patients with hyperprolinemia, proline accumulation can cause a decrease in ATPase activity, which further leads to mitochondrial stress and elevated lactate levels, and can also decrease glutamate uptake [17]

in which 56 patients with acute ischaemic stroke underwent recanalisation therapy (30 with intravenous thrombolysis, 15 with mechanical thrombectomy, and 11 with both methods combined) revealed that the plasma levels of isovalerate, one of the SCFAs, were inversely correlated with stroke severity as measured by the National Institutes of Health Stroke Scale (NIHSS) both on admission and at discharge, while TMAO levels were not associated with stroke severity (as measured by the NIHSS) or functional outcome (as measured by the Modified Rankin ScalemRS) [57]

Serum B12: The reference range for B12 in conventional medicine is 200-1100 pg/mL
