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The IRR is a heteroreceptor complex formed by the erythropoietin receptor and the beta-common receptor (CD131)

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First-in-human clinical trials, also known as FIH trials, are studies during which a drug is administered to humans for the first time after its testing in in vitro and in vivo preclinical, experimental models

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If there is enough B12 at work in the cells, it keeps these two substances down, and the results of these tests will be low