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A., Hashem, H., Saleh, H., Kamel, E

[DOI] [PMC free article] [PubMed] [Google Scholar] 173.Chen C.C., Luo J.C., Fang Y.J., Lee J.Y., Kuo C.C., Yang T.H., Chiu M.C., Yu J.J., Bair M.J., Chen P.Y., et al

[124] Other causes of B 12 malabsorption include bariatric surgery, pancreatic insufficiency, obstructive jaundice, tropical sprue, celiac disease, inherited intrinsic factor deficiency, and radiation enteritis affecting the distal ileum

The GM metabolite TMAO inhibited Cytotoxicity through activation of the nuclear receptors Farnesoid X receptor (FXR) and small heterodimer partner (SHP) to inhibit the expression of Cyp7a1, an enzyme that plays a key role in cholesterol metabolism and bile acid synthesis, reducing hepatic BA synthesis, accelerating the development of AS, and decreasing reverse cholesterol transport [61], providing further evidence of the link between gut microbiota and AS (Table 1)

In animal models, VA deficiency has been shown to result in altered neuronal excitability and increased seizure frequency, underscoring the nutrient's protective role in the central nervous system [142]