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Among the proteins, interleukin-8 (IL-8) (12), macrophage migration inhibitory factor (MIF) (13), galectin-1 (14), MK (15), IL-18 (16), galectin-3 (17), HDGF (18), osteopontin (OPN) (19), connective tissue growth factor (CTGF) (20) and GRN (21) are known to be involved in angiogenesis besides VEGF-A

This aggressive but controlled ramp-up helps the body adjust to the triple receptor activation while minimizing the gastrointestinal distress that comes with too-rapid dose increases

Using a mAb to inhibit the CD47/signalregulatory protein alpha (SIRP) axis, which is found on monocytes, also increased daratumumabmediated cell death

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This bidirectional regulation, rather than simple enhancement or inhibition, may explain BPC-157's apparent ability to promote healing in diverse pathological conditions