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And since the nutrient is water soluble, you cant take in too much

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[28] found that NNMT knockdown significantly reduced the body weight, fat mass, and insulin level of female mice fed a Western diet (fat 47% kcal, carbohydrate 34% kcal), as did NNMT knockout

Because the mechanism is appetite-based rather than metabolically suppressive, it tends to reduce intake without sapping energy
