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Moderate treatment of TMAO (6.7 mg/kg) was found to decrease diastolic dysfunction while increasing the TMAO level by four to five times in a hypertensive rat model (Huc et al., 2018)

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33 It is a substrate of CYP2C19

Interestingly, a study deciphered a mechanism by which specific tryptophan metabolites were generated, which was independent of abundances of tryptophan-metabolizing gut bacteria, but regulated in a substrate-specific manner of metabolic pathways that involved different species and cross-feeding mechanisms (57)

54 Similar findings were reported for a mixture of curcuminoids from Indian ( Curcuma domestica ) and Javanese ( Curcuma xanthorrhiza ) turmeric (P54FP)