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Real-world experience from clinical programs and observational cohorts reinforce trial data and demonstrate more heterogeneity

B12 Deficiency-Related Health Issues Symptoms for Vitamin B12 deficiency can include tiredness, tingling hands and feet, muscle weakness, depression, short memory loss, dementia, vision problems, anaemia, and low blood counts

doi:10.15252/embj.2021109470

Bristow RG, 2013, 'TMPRSS2-ERG status is not prognostic following prostate cancer radiotherapy: Implications for fusion status anddsb repair', Clinical Cancer Research , 19, pp

Neither has been tested in humans, and both carry significant unknowns -- Dihexa with its retracted publication and oncological pathway concerns, PE-22-28 with its untested cognitive effects and potential seizure susceptibility