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Upon receptor engagement in research models, IGF-1 LR3 activates two major downstream signaling cascades: - PI3K/Akt/mTOR pathway associated with cellular survival, protein synthesis, and anabolic signaling processes in experimental models

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[PMC free article] [PubMed] [Google Scholar] Patrick L, Uzick M

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On the other hand, overexpression of Nrf2 (transcriptional regulator of seleno-GPxs) contributed to the increase in the radioresistance and stemness in glioma stem cells (GSCs) by upregulating GPx1 and decreasing the cellular ROS level

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