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Therefore, methionine has to be exogenously introduced into the human body either within the diet or as a supplement.12 Methionine serves several key roles in the human body such as: Substrate in the production of critical hormones and proteins including L-cysteine, carnitine, adrenaline, choline, and melatonin, among others

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Similarly, fisetin, a flavonoid found in strawberries and other fruits, activates SIRT1 by increasing NAD + levels while also reducing oxidative stress and inflammation 179 (Fig