why do i feel so tired after b12 injection All the Time. I Need a Shot?: Shawn Veiseh, M.D.: Family Medicine Feeling worse after B12 Injection:

This occurs when serum levels are high but the B12 isnt being properly taken up by tissues

These metabolic shifts increase energy expenditure, suppress lipogenesis, and rejuvenate muscle stem cell function, providing a unique mechanism for combating obesity, fatty liver, and age-related muscle decline 1-3

not primarily appetite-driven (OUP Academic) Expected weight loss (this is where many people get misled) In major obesity trials: Semaglutide 2.4 mg weekly: ~14.9% mean weight loss at 68 weeks (STEP-1) (PubMed) Tirzepatide: ~15.0% to ~20.9% mean weight loss at 72 weeks , dose-dependent (SURMOUNT-1) (PubMed) AOD-9604s best-known human signal is kilograms, not double-digit percentages , and later studies did not sustain a strong obesity-drug profile

Vegans and vegetarians are at particular risk, since B12 is found almost entirely in animal products

Working closely with folate (vitamin B9) in the synthesis of DNA and RNA (essential for the growth and function of all cells in the body), it helps in DNA Synthesis and repair