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However, the FDA has not approved it for human use

5 -reductase isozymes are expressed in multiple tissues, and the predominant isozyme in human prostate is 5 -reductase-2

10 These authors found that stimulation of spinal neurokinin 1, NMDA, and non-NMDA receptors enhances spinal release of PGE2, which facilitates the release of spinal amino acids and peptides

An additional indicative point is sequential involvement
