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Although it is beyond the scope of this study to identify the mechanisms by which PDF leads to the activity-dependent (TTX-sensitive) upregulation of CLK/CYC-transcription, we speculate that Ca 2+ influx downstream of PDF/PDFR signalling leads to an upregulation of clock gene transcription

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Exogenous spermidine modifies nutritional and bioactive constituents of cauliflower ( Brassica oleracea var

These data showed that Ashwagandha demonstrates antidepressant-like effects in models of adolescent depression by attenuating apoptosis, neuroinflammation, and enhancing neurotrophic factors, thereby underscoring its potential as a therapeutic agent for early intervention in adolescent depressive disorders (86)