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We recently demonstrated that in HEK293 cells over-expressing IGF-1 isoforms the proIGF-1s are the main forms produced intracellularly, and for proIGF-1Ea both unglycosylated (~12 kDa) and glycosylated (~17 kDa) forms were detected 7

The cytotoxicity that results from prevention of catabolism of adenosine or deoxyadenosine is thought to be due to elevated intracellular levels of dATP, which can block DNA synthesis through inhibition of ribonucleotide reductase

[Google Scholar] 142.Chen C., Han Y., Li S., Wang R., Tao C

Fish Shellfish Immunol 134:108588 Phatnani H, Maniatis T (2015) Astrocytes in neurodegenerative disease

Anti-Inflammatory and Immunomodulatory Effects