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DiStefano, P

The research was led by Isaac Harris, an associate professor in the Department of Biomedical Genetics, and colleagues including co-first authors Fabio Hecht and Marco Zocchi, both in the Harris Lab

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The resulting downregulation of JMJD3 leads to suppressed EDNRB expression and compensatory upregulation of EDNRA, promoting endothelin-mediated vasoconstriction, ERK pathway activation, and vascular remodelingall key features of hypertension [55,56,57]