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The phenomenon of aerobic glycolysis, together with its product L-lactate, is linked to the astrocyte-to-neuron lactate shuttle 609 , a concept that considers L-lactate as an energy source for neurons

Notably, scale-up experiments revealed approximately a 20% decrease in productivity, with higher yields observed in 100 mL shake-flask cultures compared to 5 L fermenter systems

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doi: 10.1016/j.addr.2006.09.017, 117

Effect of acute melatonin injection on metabolomic and testicular artery hemodynamic changes and circulating hormones in Shiba goats under sub-tropical environmental conditions