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Non-Smad pathways in TGF-beta signaling

10.1053/j.gastro.2016.02.035 82 NanjiA

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By incorporating a viral replicon encoding nonstructural genes, saRNA constructs can amplify themselves intracellularly, prolonging protein expression and enhancing immunogenicity compared to conventional mRNA ( Nevertheless, presence of a viral replicon in the saRNA structure significantly increases its size by thousands of bases to pose stability issues

This standard dose is based on clinical evidence supporting its effectiveness in maintaining abstinence after detox