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Within the central nervous system (CNS), a population of neurons located in the posterior hypothalamus provide the sole source of neuronal histamine to the brain (46) and can be identified based on the expression of histidine decarboxylase (HDC), the enzyme required for histamine synthesis (7, 8)

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Diagnosis of familial dysbetalipoproteinemia based on the lipid abnormalities driven by APOE2/E2 genotype