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Additionally, the two-way interactions and three-way interaction between time point, treatment, and baseline value was included in the model

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p , GGsTop aliquots (25 mg/mL in H 2 O) were kept at room temperature for the indicated number of days, after which their inhibitory potency was assessed using an in vitro activity assay with mouse kidney lysates (n = 3 technical replicates)

There is growing consensus regarding their pathophysiology and management, but more work is needed to elucidate the relationships between irAEs and treatment outcomes, specific biomarkers that clinch an irAE diagnosis, the impact of tailored immunosuppression on ICI outcomes, and the management of steroid-refractory irAEs

Oncogene 35, 32013208