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Irreversible aggregates do not revert back to their monomeric forms and can be caused by the rearrangement of disulfide bonds or the formation of new structures due to hydrophobic association

Sermorelin has a half-life of around 11 to 12 minutes, meaning half of the peptide is processed by the pituitary gland within this time (5)

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Zamanian et al., 2020), but its utility still requires a more robust clinical trial to prove